How blood clots form and cause harm
Mechanisms in Blood Clotting
This work looks at how immune signals and other molecules make dangerous blood clots in people who get thrombosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11304592 on NIH RePORTER |
What this research studies
You would hear that researchers are trying to tell apart the normal clotting that stops bleeding from the harmful "immunothrombosis" that causes strokes and clots. They focus on molecules called DAMPs and PAMPs—including a molecule named polyphosphate—that seem to push the clotting system toward dangerous clot formation. The team uses laboratory experiments on blood components and disease models to find which signals drive thrombosis but are not needed for everyday bleeding control. By pinpointing those targets, they hope to guide safer treatments that block harmful clots without causing bleeding.
Who could benefit from this research
Good fit: People with a history of thrombosis or blood clotting disorders who are willing to contribute samples or participate in related clinical studies would be the best fit.
Not a fit: People with primary bleeding disorders (for example hemophilia) or conditions unrelated to thrombosis may not benefit from this work.
Why it matters
Potential benefit: If successful, this could point to new treatments that prevent dangerous clots while preserving normal bleeding control.
How similar studies have performed: Previous laboratory work—including the team's identification of polyphosphate as a prothrombotic signal—makes this a promising but still early and exploratory path toward therapies.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Morrissey, James H. — University of Michigan at Ann Arbor
- Study coordinator: Morrissey, James H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.