How blood cell mutations affect heart disease in women who experience early menopause
Official title: Clonal hematopoiesis as a mediator of cardiovascular disease in women with premature menopause
Funded at Massachusetts General Hospital · NIH-11004995 · Data updated 2026-11-12
This study is looking at how changes in blood stem cells might affect heart health in women who have gone through menopause early, and it aims to find ways to prevent or treat heart disease in this group.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2023 |
| Project end | March 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $169,003 |
| NIH project number | 5K08HL166687-03 |
| Project ID | NIH-11004995 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have experienced premature menopause and may have cardiovascular disease risk factors.
✕Less likely to help
Patients who have not experienced premature menopause or do not have cardiovascular disease may not benefit from this research.
What this research studies
This research investigates the relationship between clonal hematopoiesis, a condition where certain blood stem cells develop mutations, and cardiovascular disease in women who have undergone premature menopause. The study aims to understand how these mutations may accelerate heart disease in this specific population. By utilizing advanced techniques and multi-omics approaches, the research seeks to uncover the mechanisms behind this association and identify potential targets for prevention and treatment. Patients may be involved in providing samples and data to help elucidate these connections.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and treatments for heart disease in women who experience early menopause.
How similar studies have gone: Previous research has indicated a link between clonal hematopoiesis and cardiovascular disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Honigberg, Michael — Massachusetts General Hospital
- Study coordinator: Honigberg, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.