How blocking CD47 can help fight melanoma spread
Therapeutic Mechanism of CD47 Blockade in Suppressing Melanoma Metastasis
This study is looking at how melanoma cells hide from the immune system and how blocking a protein called CD47 might help the immune system fight back better, with the hope of finding better treatments for patients with advanced melanoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11055981 on NIH RePORTER |
What this research studies
This research investigates how melanoma cells evade the immune system and how blocking a protein called CD47 can help overcome this suppression. By studying the molecular mechanisms behind CD47's role in immune evasion, the research aims to identify specific targets that can enhance the immune response against metastatic melanoma. The approach includes using patient-derived xenograft (PDX) models that closely mimic human disease, allowing for more relevant findings. Ultimately, the goal is to improve patient selection for therapies that could lead to better outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic melanoma who may benefit from enhanced immune therapies.
Not a fit: Patients with non-melanoma skin cancers or those who do not have metastatic disease may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for melanoma, potentially improving survival rates for patients.
How similar studies have performed: Previous research has shown promising results with CD47 blockade in other cancer types, suggesting potential for success in melanoma as well.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Boiko, Alexander D — Cedars-Sinai Medical Center
- Study coordinator: Boiko, Alexander D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.