How bleeding in the brain affects the protective barrier in premature infants
Intraventricular Hemorrhage Disrupts the Blood Brain Barrier in Premature Infants
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11036358
This study is looking at how bleeding in the brain affects the protective barrier around it in premature babies, and it aims to find ways to help prevent serious problems like cerebral palsy by exploring certain substances that could help keep that barrier strong.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11036358 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of intraventricular hemorrhage (IVH) on the blood-brain barrier (BBB) in premature infants. It focuses on how IVH leads to inflammation and disrupts the BBB, which can result in severe neurological complications such as cerebral palsy and cognitive deficits. The study explores the role of specific lipid mediators, particularly sphingosine 1 phosphate (S1P), in regulating the function of the BBB and how manipulating these pathways could provide neuroprotection. By understanding these mechanisms, the research aims to identify potential therapeutic targets to prevent the adverse effects of IVH.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who experience intraventricular hemorrhage.
Not a fit: Patients who are not premature or do not have a history of intraventricular hemorrhage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent neurological damage in premature infants suffering from intraventricular hemorrhage.
How similar studies have performed: Previous research has shown promising results in manipulating the pathways involved in blood-brain barrier function, indicating potential for success in this area.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BALLABH, PRAVEEN — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: BALLABH, PRAVEEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury