How biomolecular condensates affect gene transcription in cells
Official title: Structural and functional determinants of biomolecular condensates in transcription organization
Funded at University of Illinois at Chicago · NIH-10933412 · Data updated 2026-11-12
This study is looking at how tiny structures in our cells, called biomolecular condensates, help control how genes are turned on and off, using special imaging techniques to see how they interact with the DNA in mouse stem cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $388,043 |
| NIH project number | 5R35GM150560-02 |
| Project ID | NIH-10933412 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that involve transcriptional regulation issues.
✕Less likely to help
Patients with conditions unrelated to transcriptional regulation or those not affected by chromatin organization may not benefit from this research.
What this research studies
This research investigates how biomolecular condensates, which are membraneless organelles in the cell nucleus, influence gene transcription. By using advanced microscopy techniques, the study aims to observe the relationship between chromatin organization and the formation of these condensates in mouse embryonic stem cells. The researchers will analyze how specific chromatin features and epigenetic modifications contribute to the regulation of transcription at a genomic level. This approach could provide insights into the mechanisms that govern gene expression and cellular function.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene regulation, potentially informing new treatments for diseases linked to transcriptional dysregulation.
How similar studies have gone: While the specific approach of this research is novel, related studies have shown promise in understanding the role of biomolecular condensates in cellular processes.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Spille, Jan-Hendrik — University of Illinois at Chicago
- Study coordinator: Spille, Jan-Hendrik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.