How bioactive lipids affect sensory ion channels in the body
Sensory Ion Channel Modulation by Bioactive Lipids
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11014040
This study is looking at how certain fats in our body can affect special channels that help us feel things like pain and temperature, with the hope of finding better ways to treat conditions like chronic pain, nerve issues from diabetes, and heart problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11014040 on ClinicalTrials.gov |
What this research studies
This research investigates how bioactive lipids influence the function of transient receptor potential (TRP) ion channels, which are crucial for detecting various stimuli and regulating physiological processes. By exploring the mechanisms of how these lipids modulate TRP channels, the research aims to identify new strategies that could improve treatment options for conditions like pain hypersensitivity, diabetes-related neuropathies, and cardiovascular diseases. The study employs a combination of laboratory techniques and animal models to understand the effects of specific lipids on TRP channel function and their potential therapeutic benefits.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to TRP channel dysfunction, such as diabetes, chronic pain, or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to TRP channel dysfunction or those not experiencing symptoms related to the targeted conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from pain, diabetes, and other related disorders by fine-tuning TRP channel function.
How similar studies have performed: Previous research has shown promise in modulating TRP channels with bioactive lipids, indicating potential for success in this novel approach.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CORDERO-MORALES, JULIO F — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: CORDERO-MORALES, JULIO F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: blood vessel disorder, Cardiovascular Diseases, cardiovascular disorder