How bioactive lipids affect sensory ion channels in the body
Official title: Sensory Ion Channel Modulation by Bioactive Lipids
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11014040 · Data updated 2026-11-12
This study is looking at how certain fats in our body can affect special channels that help us feel things like pain and temperature, with the hope of finding better ways to treat conditions like chronic pain, nerve issues from diabetes, and heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $351,000 |
| NIH project number | 5R35GM149218-04 |
| Project ID | NIH-11014040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions related to TRP channel dysfunction, such as diabetes, chronic pain, or cardiovascular diseases.
✕Less likely to help
Patients with conditions unrelated to TRP channel dysfunction or those not experiencing symptoms related to the targeted conditions may not benefit from this research.
What this research studies
This research investigates how bioactive lipids influence the function of transient receptor potential (TRP) ion channels, which are crucial for detecting various stimuli and regulating physiological processes. By exploring the mechanisms of how these lipids modulate TRP channels, the research aims to identify new strategies that could improve treatment options for conditions like pain hypersensitivity, diabetes-related neuropathies, and cardiovascular diseases. The study employs a combination of laboratory techniques and animal models to understand the effects of specific lipids on TRP channel function and their potential therapeutic benefits.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from pain, diabetes, and other related disorders by fine-tuning TRP channel function.
How similar studies have gone: Previous research has shown promise in modulating TRP channels with bioactive lipids, indicating potential for success in this novel approach.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Cordero-Morales, Julio F — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Cordero-Morales, Julio F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.