How bile acids affect norovirus infections in children and adults
Regulation of enteric norovirus infection by host-derived and microbiota-transformed bile acids
This study is looking at how substances in our gut, called bile acids, can change the way norovirus affects babies, especially how breast milk might help protect them from getting sick.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11125012 on NIH RePORTER |
What this research studies
This research investigates how bile acids, which are influenced by gut microbiota, affect norovirus infections. It focuses on understanding the mechanisms by which these bile acids can either promote or inhibit infections, particularly in neonates who are more vulnerable. The study will explore the impact of altering bile acid levels and the role of maternal breast milk in protecting infants from norovirus-related diarrhea. By examining these factors, the research aims to identify new therapeutic targets for treating norovirus infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and young children, as well as adults who are affected by norovirus infections.
Not a fit: Patients who are not affected by norovirus infections or those who do not have a history of gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the severity of norovirus infections, especially in vulnerable populations like infants.
How similar studies have performed: Previous research has shown that understanding the role of microbiota in infections can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Karst, Stephanie M — University of Florida
- Study coordinator: Karst, Stephanie M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.