How beta-amyloid deposits affect blood vessels in the brain of older adults
Official title: Induction of Neutrophil Extracellular Traps by Beta-Amyloid Deposits in Cerebral Amyloid Angiopathy
Funded at University of Rhode Island · NIH-11093967 · Data updated 2026-11-12
This study is looking at how certain deposits in the brain affect blood vessels in older adults with a condition called cerebral amyloid angiopathy, which is often linked to Alzheimer's disease, to help find new ways to treat it.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $157,500 |
| NIH project number | 5R03AG085082-02 |
| Project ID | NIH-11093967 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 80 and over who are experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients under the age of 80 or those without symptoms of Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research investigates the impact of beta-amyloid deposits on blood vessels in the brain, particularly in older adults with cerebral amyloid angiopathy (CAA), a condition often associated with Alzheimer's disease. The study aims to understand the mechanisms by which these deposits lead to inflammation and vascular damage, which can contribute to cognitive decline. Using a specialized rat model that mimics human CAA, researchers will explore how neutrophils and their extracellular traps may play a role in this process. The findings could provide insights into potential therapeutic targets for treating CAA and related dementias.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients suffering from cerebral amyloid angiopathy and related cognitive impairments.
How similar studies have gone: While the specific mechanisms being studied are novel, there is existing research indicating that neutrophil-mediated inflammation plays a role in other chronic inflammatory disorders, suggesting potential pathways for success.
Where this research is happening
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University of Rhode Island
Kingston, United States Active
Researchers
- Principal investigator: Schrader, Joseph M — University of Rhode Island
- Study coordinator: Schrader, Joseph M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.