How beta-amyloid deposits affect blood vessels in the brain of older adults
Induction of Neutrophil Extracellular Traps by Beta-Amyloid Deposits in Cerebral Amyloid Angiopathy
This study is looking at how certain deposits in the brain affect blood vessels in older adults with a condition called cerebral amyloid angiopathy, which is often linked to Alzheimer's disease, to help find new ways to treat it.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project ID | NIH-11093967 on NIH RePORTER |
What this research studies
This research investigates the impact of beta-amyloid deposits on blood vessels in the brain, particularly in older adults with cerebral amyloid angiopathy (CAA), a condition often associated with Alzheimer's disease. The study aims to understand the mechanisms by which these deposits lead to inflammation and vascular damage, which can contribute to cognitive decline. Using a specialized rat model that mimics human CAA, researchers will explore how neutrophils and their extracellular traps may play a role in this process. The findings could provide insights into potential therapeutic targets for treating CAA and related dementias.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 80 and over who are experiencing symptoms of Alzheimer's disease or related dementias.
Not a fit: Patients under the age of 80 or those without symptoms of Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients suffering from cerebral amyloid angiopathy and related cognitive impairments.
How similar studies have performed: While the specific mechanisms being studied are novel, there is existing research indicating that neutrophil-mediated inflammation plays a role in other chronic inflammatory disorders, suggesting potential pathways for success.
Where this research is happening
Kingston, United States
- University of Rhode Island — Kingston, United States (Active)
Researchers
- Principal investigator: Schrader, Joseph M — University of Rhode Island
- Study coordinator: Schrader, Joseph M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.