How BDNF affects brain inflammation and mood
Role of Brain-Derived Neurotrophic Factor in Regulating Neuroinflammation in Mental Health
This project looks at whether changes in the brain protein BDNF drive inflammation in the brain that may worsen depression, especially in veterans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | South Texas Veterans Health Care System NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11131033 on NIH RePORTER |
What this research studies
If you have experienced long-term stress or depression, this work examines how a brain protein called BDNF might change immune activity in the brain and contribute to depressive symptoms. Researchers use laboratory models and molecular studies to look at how BDNF influences two arms of the kynurenine pathway in brain cells called astrocytes and microglia. The team is identifying neural pathways that can be targeted to lower harmful inflammation while preserving protective processes. Results are intended to point toward new treatment strategies for people with inflammation-linked depression, including many US veterans.
Who could benefit from this research
Good fit: Adults (age 21+) with a history of chronic stress or depression, particularly US veterans with inflammation-related health issues, would be the most relevant candidates.
Not a fit: People without depressive symptoms or without signs of brain or systemic inflammation—including children under 21—are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work may identify new targets to reduce brain inflammation and improve treatments for inflammation-linked depression.
How similar studies have performed: Previous studies have linked BDNF and the kynurenine pathway to depression, so elements are supported by prior work, but the specific focus on BDNF-driven neuroinflammation in veterans is relatively novel.
Where this research is happening
San Antonio, United States
- South Texas Veterans Health Care System — San Antonio, United States (Active)
Researchers
- Principal investigator: O'connor, Jason C — South Texas Veterans Health Care System
- Study coordinator: O'connor, Jason C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.