How BCL2 protein changes affect HIV infection and treatment response
IMPACT OF BCL2 PHOSPHORYLATION ON HIV DYNAMICS, RESERVOIR SIZE AND SUSCEPTIBILITY TO VENETOCLAX
['FUNDING_OTHER'] · MAYO CLINIC ROCHESTER · NIH-11118296
This study is looking at how a protein called BCL2 changes during HIV infection and how that affects the way a drug called Venetoclax works, with the goal of finding better ways to treat people living with HIV.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11118296 on ClinicalTrials.gov |
What this research studies
This research investigates the role of BCL2 protein phosphorylation in the dynamics of HIV infection and how it influences the effectiveness of the drug Venetoclax. By examining T cells that persist after HIV infection, the study aims to understand how modifications to BCL2 can affect cell death and the size of the HIV reservoir in the body. The researchers will utilize advanced techniques, including CRISPR technology, to create specific cell lines that will help them analyze the interactions between BCL2, HIV replication, and treatment responses. This work could lead to improved strategies for targeting HIV-infected cells and enhancing treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have not achieved viral suppression or have a high viral load.
Not a fit: Patients who are not infected with HIV or those who have achieved long-term viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for HIV by enhancing the ability to eliminate infected cells.
How similar studies have performed: Previous research has shown promising results with Venetoclax in targeting HIV-infected cells, indicating that this approach has potential for success.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BADLEY, ANDREW D — MAYO CLINIC ROCHESTER
- Study coordinator: BADLEY, ANDREW D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus