How BAP1 gene mutations affect cancer development
Mechanisms of BAP1 activity in human cancer development
This study is looking at how changes in the BAP1 gene, especially in families with these changes, work together with things like asbestos exposure to increase the risk of developing malignant mesothelioma and other cancers, with the goal of finding better ways to prevent and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project ID | NIH-10747923 on NIH RePORTER |
What this research studies
This research investigates how genetic mutations in the BAP1 gene interact with environmental factors, such as exposure to asbestos, to influence the development of malignant mesothelioma and other cancers. It focuses on understanding the mechanisms behind increased cancer susceptibility in individuals with BAP1 mutations, particularly in families where these mutations are common. By studying the effects of these mutations in conjunction with environmental carcinogens, the research aims to uncover the pathways that lead to cancer development, which could ultimately inform prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of BAP1 mutations or those who have been exposed to asbestos and are concerned about their cancer risk.
Not a fit: Patients without a family history of BAP1 mutations or those who have not been exposed to known carcinogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cancer risk for individuals with BAP1 mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic mutations in cancer susceptibility, making this approach both relevant and potentially impactful.
Where this research is happening
Honolulu, United States
- University of Hawaii at Manoa — Honolulu, United States (Active)
Researchers
- Principal investigator: Carbone, Michele — University of Hawaii at Manoa
- Study coordinator: Carbone, Michele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.