How bacteriophages recognize and attach to bacteria
Structural and functional determinants of decision-making in bacteriophage host recognition
This study is looking at how certain viruses called bacteriophages find and stick to bacteria, especially E. coli, which could help us develop new ways to use these viruses to treat bacterial infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10650340 on NIH RePORTER |
What this research studies
This research investigates how bacteriophages, which are viruses that infect bacteria, identify and attach to their host cells. It focuses on specialized proteins that help these viruses bind to bacterial surfaces, particularly in Escherichia coli. By examining the structural changes that occur during this attachment process, the research aims to uncover the mechanisms that enable phages to deliver their genetic material into bacterial cells. This understanding could lead to new strategies for using bacteriophages in treating bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria, particularly those involving E. coli.
Not a fit: Patients with infections that are not caused by bacteria or those who do not have antibiotic-resistant infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the development of phage therapies to combat antibiotic-resistant bacterial infections.
How similar studies have performed: Other research has shown promise in using bacteriophages to treat bacterial infections, indicating that this approach has potential for success.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Leiman, Petr G — University of Texas Med Br Galveston
- Study coordinator: Leiman, Petr G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.