How bacteriophages interact with and affect bacteria during infection
Mechanisms of interaction between bacteriophage and their hosts throughout the infection cycle
This study is looking at how certain viruses that attack bacteria, called Moogleviruses, can help fight tough infections caused by harmful bacteria like Shigella flexneri, especially when traditional antibiotics don't work anymore.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11078839 on NIH RePORTER |
What this research studies
This research investigates the interactions between bacteriophages, which are viruses that infect bacteria, and their bacterial hosts throughout the infection cycle. The study focuses on understanding how these phages infect bacteria, replicate, and influence both their own genes and those of the bacteria. By exploring a specific group of bacteriophages known as Moogleviruses, which target harmful bacteria like Shigella flexneri, the research aims to develop new strategies for combating antibiotic-resistant infections. This could lead to innovative treatments for bacterial infections that are difficult to manage with traditional antibiotics.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by antibiotic-resistant bacteria, particularly those involving Shigella flexneri.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria or those not affected by Shigella flexneri may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for patients suffering from antibiotic-resistant bacterial infections.
How similar studies have performed: Other research has shown promise in using bacteriophages to treat bacterial infections, indicating that this approach could be effective.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Doore, Sarah M — University of Florida
- Study coordinator: Doore, Sarah M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.