How bacterial communication affects their growth and survival
Official title: Peptide cues in the environment regulate bacterial dormancy
Funded at Salve Regina University · NIH-10874289 · Data updated 2026-11-12
This study looks at how E. coli bacteria talk to each other using tiny signals in their surroundings, which helps them decide when to rest or stay active, and it also gives students a chance to learn about this fascinating process.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salve Regina University NIH-funded |
| Lab location | 1 site (Newport, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $387,866 |
| NIH project number | 1R15GM154245-01 |
| Project ID | NIH-10874289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with infections caused by antibiotic-resistant bacteria may benefit from the findings of this research.
✕Less likely to help
Patients with non-bacterial infections or those not affected by antibiotic resistance may not receive any benefit from this research.
What this research studies
This research investigates how bacteria communicate through molecular cues in their environment, particularly focusing on how these signals influence bacterial dormancy and survival. By studying a specific strain of E. coli, the project aims to identify the molecules involved in this communication and the genetic responses they trigger. The research employs a combination of synthetic chemistry, bacterial genetics, and proteomics to uncover the mechanisms of bacterial crosstalk. This work also includes training undergraduate students in relevant scientific disciplines, enhancing their educational experience.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic resistance in pathogenic bacteria.
How similar studies have gone: Previous research has shown that understanding bacterial communication can lead to breakthroughs in treating infections, suggesting that this approach has potential for success.
Where this research is happening
-
Salve Regina University
Newport, United States Active
Researchers
- Principal investigator: Meschwitz, Susan — Salve Regina University
- Study coordinator: Meschwitz, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.