How bacteria trigger immune and stress responses in the body
Pathogen-induced immune and stress responses mediated by bZIP transcription factors
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10901920
This study is looking at how certain bacteria can cause infections and trigger the body's immune response, using tiny worms to help understand how these bacteria produce a substance that can harm cells and activate stress responses, which could help us learn more about how our bodies react to infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10901920 on ClinicalTrials.gov |
What this research studies
This research investigates how certain bacteria, specifically the mitis group streptococci, can cause infections and activate immune responses in the body. By using a model organism called Caenorhabditis elegans, the study aims to understand the mechanisms behind the bacteria's ability to produce hydrogen peroxide, which can lead to cell death and activate stress pathways. The researchers will focus on specific transcription factors that mediate these responses, providing insights into the body's reaction to bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced infections related to the mitis group streptococci, such as bacteremia or septic arthritis.
Not a fit: Patients with infections caused by other types of bacteria not related to the mitis group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by these bacteria.
How similar studies have performed: Other research has shown success in understanding bacterial pathogenesis and immune responses, making this approach promising yet still exploring novel aspects.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN DER HOEVEN, RANSOME — UNIVERSITY OF IOWA
- Study coordinator: VAN DER HOEVEN, RANSOME
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.