How bacteria organize their internal structures
Coordinated Spatial Organization in Bacteria
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11013888
This study looks at how certain bacteria, like Halothiobacillus neapolitanus, organize their important parts without using typical motor proteins, focusing on a special group of proteins that help keep everything in the right place, which could help us learn more about how bacteria work and cause diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11013888 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which bacteria organize their internal components without linear motor proteins. It focuses on a family of proteins called A/D ATPases that help position various cellular structures essential for bacterial function and survival. By studying a specific nonpathogenic bacterium, Halothiobacillus neapolitanus, the research aims to uncover how these proteins coordinate the placement of critical cellular elements, which could have implications for understanding bacterial behavior and pathogenicity. The approach includes detailed bioimaging and genetic analysis to explore the roles of these proteins in cellular organization.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals affected by bacterial infections, particularly those caused by pathogens that utilize similar organizational mechanisms.
Not a fit: Patients with viral infections or non-bacterial diseases may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting bacterial pathogens by disrupting their internal organization.
How similar studies have performed: Other research has shown success in understanding bacterial mechanisms, but this specific approach focusing on A/D ATPases is relatively novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VECCHIARELLI, ANTHONY G — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: VECCHIARELLI, ANTHONY G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.