How bacteria manage their metabolism and resist antibiotics
Official title: Gene Regulation and Memory in Bacterial Metabolism and Antibiotic Resistance
Funded at New York University · NIH-10979160 · Data updated 2026-11-12
This study is looking at how bacteria change their behavior to survive in different environments, especially when faced with antibiotics, to help us understand why some bacteria can resist treatment and how they remember past challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $290,799 |
| NIH project number | 5R01GM148703-03 |
| Project ID | NIH-10979160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients suffering from infections caused by antibiotic-resistant bacteria would be ideal candidates to benefit from this research.
✕Less likely to help
Patients with infections caused by non-bacterial pathogens or those not affected by antibiotic resistance may not receive benefit from this research.
What this research studies
This research investigates how bacteria adapt their metabolism in response to environmental changes, particularly focusing on their ability to resist antibiotics. By examining the genetic regulation of bacterial responses, the study aims to understand how bacteria can survive and thrive despite antibiotic exposure. The researchers will utilize advanced techniques such as microfluidics and sequencing to analyze bacterial behavior and gene expression in fluctuating environments. This work could reveal new insights into the mechanisms of antibiotic resistance and how bacteria can 'remember' past stresses to improve their survival.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic resistance in bacterial infections.
How similar studies have gone: Previous research has shown success in understanding bacterial resistance mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Kussell, Edo L — New York University
- Study coordinator: Kussell, Edo L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.