How bacteria manage protein production during times of rest
Regulation of protein synthesis during quiescence in bacteria
This study looks at how a type of bacteria called Bacillus subtilis manages to save energy and resources when it's not growing, helping us understand how they survive tough conditions and quickly bounce back when things get better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11005286 on NIH RePORTER |
What this research studies
This research investigates how bacteria, specifically Bacillus subtilis, regulate protein synthesis when they are not actively growing. It focuses on the mechanisms that allow these bacteria to conserve energy and resources during periods of quiescence, which is essential for their survival in nutrient-limited or stressful environments. The study aims to understand the balance between reducing protein production and being able to quickly resume it when conditions improve. By examining the energy-intensive process of protein synthesis, the research seeks to uncover how bacteria adapt their metabolic processes to ensure survival.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals interested in microbial health or those affected by bacterial infections.
Not a fit: Patients with conditions unrelated to bacterial infections or microbial metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing bacterial growth and survival, which may have implications for antibiotic development and microbial management.
How similar studies have performed: Other research has shown success in understanding bacterial metabolism and regulation, indicating that this approach is built on established scientific principles.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Dworkin, Jonathan — Columbia University Health Sciences
- Study coordinator: Dworkin, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.