How bacteria interact with the cells lining the intestines
Novel cytoskeletal mechanisms of pathogenic bacteria interactions with intestinal epithelium
This study is looking at how harmful bacteria, like E. coli, stick to and invade the cells in our intestines, and it focuses on a special protein that helps with this process, with the goal of finding new ways to prevent or treat infections from bacteria that don't respond to antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11085097 on NIH RePORTER |
What this research studies
This research investigates how certain pathogenic bacteria, like E. coli, attach to and invade intestinal epithelial cells, which are crucial for gut health. The study focuses on the role of a specific protein, non-muscle myosin II, in facilitating these interactions by altering the structure of the cell's cytoskeleton. By understanding these mechanisms, researchers aim to identify potential therapeutic targets to prevent or treat infections caused by antibiotic-resistant bacteria. The approach includes both laboratory experiments and in vivo models to observe these interactions in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from gastrointestinal disorders related to bacterial infections, particularly those caused by E. coli.
Not a fit: Patients with gastrointestinal disorders not related to bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gastrointestinal infections caused by antibiotic-resistant bacteria.
How similar studies have performed: Previous research has shown promising results in understanding bacterial interactions with intestinal cells, but this specific focus on non-muscle myosin II is relatively novel.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Ivanov, Andrei Ivanovich — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ivanov, Andrei Ivanovich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.