How bacteria form and break down protective communities in hosts
Host-associated biofilm formation and dispersal mechanisms
['FUNDING_OTHER'] · LOYOLA UNIVERSITY CHICAGO · NIH-11078184
This study looks at how certain bacteria work together to form protective layers in animals, using the bobtail squid and its helpful bacteria as an example, to help us learn how to better tackle tough bacterial infections that can affect patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY CHICAGO (nih funded) |
| Locations | 1 site (MAYWOOD, UNITED STATES) |
| Trial ID | NIH-11078184 on ClinicalTrials.gov |
What this research studies
This research investigates how pathogenic and symbiotic bacteria form protective communities known as biofilms within animal hosts. By using a model involving the bobtail squid and its symbiotic bacterium, Vibrio fischeri, the research aims to visualize and quantify biofilm formation and dispersal. The study will explore the genetic factors that influence these processes, which are crucial for understanding bacterial infections that are difficult to treat. Patients may benefit from insights gained into how to disrupt harmful biofilms and improve treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic infections associated with biofilm formation, such as those with implanted medical devices or persistent bacterial infections.
Not a fit: Patients with acute infections that do not involve biofilm formation may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by biofilm-forming bacteria.
How similar studies have performed: Other research has shown success in understanding biofilm dynamics, but this specific approach using the squid model is relatively novel.
Where this research is happening
MAYWOOD, UNITED STATES
- LOYOLA UNIVERSITY CHICAGO — MAYWOOD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VISICK, KAREN L — LOYOLA UNIVERSITY CHICAGO
- Study coordinator: VISICK, KAREN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.