How bacteria control their growth and antibiotic production using a specific signaling molecule
Official title: The control of sporulation and antibiotic production through c-di-GMP signaling
Funded at Cornell University · NIH-11019404 · Data updated 2026-11-12
This study is looking at how a special molecule called c-di-GMP affects the growth and antibiotic production in certain bacteria, which could help us understand how these bacteria change their behavior and make antibiotics when their environment changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $383,746 |
| NIH project number | 1R35GM156858-01 |
| Project ID | NIH-11019404 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals interested in the development of new antibiotics or those affected by antibiotic-resistant infections.
✕Less likely to help
Patients with conditions unrelated to bacterial infections or antibiotic treatments may not benefit from this research.
What this research studies
This research investigates how the signaling molecule 3’,5’-cyclic diguanylic acid (c-di-GMP) influences the growth and antibiotic production in bacteria, specifically in the Streptomyces genus. By studying the mechanisms of c-di-GMP signaling, the research aims to uncover how bacteria transition from growth to producing spores and antibiotics in response to environmental changes. The project will utilize advanced molecular techniques to explore gene regulation and the evolutionary aspects of this signaling pathway, which could lead to new insights into bacterial behavior and antibiotic development.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for enhancing antibiotic production in bacteria, potentially addressing antibiotic resistance.
How similar studies have gone: Previous research has shown promising results in understanding bacterial signaling mechanisms, indicating that this approach could yield significant advancements.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Gallagher, Kelley Ann — Cornell University
- Study coordinator: Gallagher, Kelley Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.