How bacteria affect healing in the larynx after injury
Official title: Microbial modulation of mucosal wound healing in the larynx
Funded at University of Wisconsin-Madison · NIH-11053543 · Data updated 2026-11-12
This study is looking at how bacteria in the throat can help heal injuries like surgery or trauma, and it aims to find ways to improve recovery for people with voice problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $187,715 |
| NIH project number | 5R21DC021012-02 |
| Project ID | NIH-11053543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing voice disorders due to laryngeal injuries or inflammation.
✕Less likely to help
Patients with voice disorders not related to laryngeal injuries or those with chronic conditions unrelated to bacterial influence may not benefit from this research.
What this research studies
This research investigates the role of bacteria in the healing process of the larynx after injuries such as surgery or trauma. By studying the microbial communities present in the larynx, the researchers aim to understand how these bacteria can influence inflammation and tissue regeneration. The study will utilize a specialized model to observe the healing stages and measure the impact of different bacterial species on the recovery of laryngeal tissue. Patients with voice disorders may benefit from insights gained about how to improve healing and reduce complications.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for voice disorders by enhancing mucosal healing in the larynx.
How similar studies have gone: While research on the laryngeal microbiome is limited, similar studies in other mucosal systems have shown promising results in understanding microbial roles in healing.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: An, Ran — University of Wisconsin-Madison
- Study coordinator: An, Ran
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.