How bacteria affect brain inflammation and neurodegenerative diseases
Bacterial disruption of neuroimmune pathways in a transparent brain
This study is looking at how bacteria and our immune system interact with brain cells, which can lead to inflammation related to diseases like Alzheimer's, using zebrafish to see these processes in action and help us understand more about what causes these brain conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11009680 on NIH RePORTER |
What this research studies
This research investigates the interactions between bacteria, the immune system, and neurons, focusing on how these interactions contribute to neuroinflammation, which is linked to conditions like Alzheimer's disease. Using a transparent zebrafish model, researchers will observe how bacteria invade the brain and trigger inflammatory responses in real-time. The study employs advanced techniques such as optogenetics and biosensors to explore the molecular mechanisms involved in these processes. By understanding these interactions, the research aims to shed light on the underlying causes of neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with neurodegenerative diseases, particularly Alzheimer's disease.
Not a fit: Patients with neurodegenerative diseases unrelated to bacterial infections or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for treating neurodegenerative diseases like Alzheimer's.
How similar studies have performed: Other research has shown promising results in understanding the role of bacteria in neuroinflammation, making this approach both innovative and grounded in prior findings.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Madigan, Cressida Arianna — University of California, San Diego
- Study coordinator: Madigan, Cressida Arianna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.