How B3GNT7 affects intestinal mucus and gut bacteria
Official title: The Impact of B3GNT7 on Properties of Intestinal Mucus and the Gut Microbiome
Funded at Ut Southwestern Medical Center · NIH-10856903 · Data updated 2026-11-12
This study is looking at how a specific enzyme that helps make mucus in the gut affects the balance of good and bad bacteria, which could help us understand conditions like Crohn's disease better, and we’d love to have patients share their samples or information to support this research!
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $40,242 |
| NIH project number | 5F30DK136209-02 |
| Project ID | NIH-10856903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with Crohn's disease or other inflammatory bowel diseases.
✕Less likely to help
Patients without gastrointestinal disorders or those not affected by gut microbiome imbalances may not benefit from this research.
What this research studies
This research investigates the role of B3GNT7, an enzyme involved in the production of intestinal mucus, and its impact on the gut microbiome. By analyzing how changes in mucus composition affect the balance of beneficial and harmful bacteria in the gut, the study aims to understand the relationship between mucus properties and conditions like Crohn's disease. Patients may be involved in providing samples or data to help identify how these biological processes influence gut health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing inflammatory bowel diseases by improving gut health.
How similar studies have gone: Previous research has shown promising results in understanding the gut microbiome's role in health and disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Burns, Mary Wilton Newton — Ut Southwestern Medical Center
- Study coordinator: Burns, Mary Wilton Newton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.