How B cells respond to insulin in obesity and insulin resistance
The B Cell Insulin Receptor in Health and in Insulin Resistance
This study looks at how certain immune cells called B cells behave in people with obesity and insulin resistance, aiming to understand how these cells might affect insulin sensitivity and overall immune health, which could help find new ways to improve health for those dealing with obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project ID | NIH-10994680 on NIH RePORTER |
What this research studies
This research investigates the role of B cells in the development of insulin resistance associated with obesity. It explores how insulin affects B cell behavior, including their proliferation and production of inflammatory proteins and antibodies. By studying both early and late stages of obesity, the research aims to understand the mechanisms behind insulin resistance and its impact on immune function. The findings could provide insights into potential therapeutic targets for improving insulin sensitivity and immune response in obese individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and experiencing insulin resistance or related metabolic issues.
Not a fit: Patients who are not obese or do not have insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity-related insulin resistance and type 2 diabetes.
How similar studies have performed: Other research has shown promising results in understanding the immune response in obesity, making this approach both relevant and potentially impactful.
Where this research is happening
Novato, United States
- Buck Institute for Research on Aging — Novato, United States (Active)
Researchers
- Principal investigator: Winer, Dan — Buck Institute for Research on Aging
- Study coordinator: Winer, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.