How B cells form and are selected by the immune system
Cellular and molecular analysis of B lymphocyte development and selection
Researchers are exploring the molecular signals that control how bone marrow stem cells make B cells, with relevance for people with blood or immune conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11332634 on NIH RePORTER |
What this research studies
This research looks at how bone marrow stem cells make B cells, which are important for your immune system. Researchers use advanced imaging like two-photon microscopy and molecular tests to watch cells and study signals such as PI3K/AKT and certain cell receptors. They work with human cells and laboratory models to understand why some stem cells stay dormant while others divide and become B cells. Learning these signals could point to new approaches for treating blood and immune disorders in the future.
Who could benefit from this research
Good fit: Adults with blood or immune disorders or healthy adult volunteers willing to donate blood or bone marrow samples would be the most relevant people to participate or contribute samples.
Not a fit: People with conditions unrelated to blood or the immune system, or those unwilling to provide samples, are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that better control blood and immune cell production for people with hematologic or immune diseases.
How similar studies have performed: Previous laboratory studies have identified parts of the PI3K/AKT signaling pathway and B cell selection mechanisms, but applying this knowledge to human stem cell balance is still an area of active and relatively novel research.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Pereira, Joao — Yale University
- Study coordinator: Pereira, Joao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.