How astrocytes work together to support brain function
Functional plasticity of astrocyte syncytial network
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10782450
This study is looking at how special brain cells called astrocytes help keep the brain's electrical activity balanced, which is important for good communication between brain cells, and it aims to find out how problems with these cells might affect brain function, potentially leading to new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10782450 on ClinicalTrials.gov |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in maintaining the balance of electrical activity and neurotransmission in the brain. By studying how these cells communicate and work together, the research aims to understand how disruptions in their function can affect neuronal excitability and synaptic transmission. The approach involves examining the signaling pathways that regulate the electrical connections between astrocytes, particularly focusing on the influence of neurotransmitters like norepinephrine and glutamate. This could provide insights into the fundamental mechanisms of brain function and potential targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders that may be linked to astrocyte dysfunction.
Not a fit: Patients with non-neurological conditions or those whose symptoms are not related to astrocyte function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders by restoring proper astrocyte function and improving neuronal communication.
How similar studies have performed: Other research has shown promising results in understanding astrocyte function and its implications for neurological health, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, MIN — OHIO STATE UNIVERSITY
- Study coordinator: ZHOU, MIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.