How astrocytes affect cognition and cognitive disorders
Role of astrocyte-based cholinergic neuromodulation in cognition and in the treatment of cognitive disorders
This study is looking at how brain cells called astrocytes help with thinking and memory, and it hopes to find new ways to improve cognitive problems, especially for people with schizophrenia, by understanding how these cells communicate with other brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11067793 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of glial cell in the brain, in cognitive functions and their potential in treating cognitive disorders. The study focuses on how astrocytes communicate with neurons through cholinergic signaling, particularly involving the α7 nicotinic acetylcholine receptors. By understanding these mechanisms, the research aims to explore new therapeutic strategies for cognitive deficits, especially in conditions like schizophrenia. Patients may benefit from insights into how enhancing astrocyte function could improve cognitive outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who experience cognitive deficits, particularly those related to schizophrenia.
Not a fit: Patients with cognitive disorders not linked to astrocyte function or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive function in patients with cognitive disorders.
How similar studies have performed: Previous research has shown promising results in targeting astrocytes for cognitive enhancement, indicating that this approach may be viable.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Papouin, Thomas — Washington University
- Study coordinator: Papouin, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.