How astrocytes affect brain recovery after a stroke
Astrocytes-Mediated Regulation of Wnt/b-Catenin Pathway in Ischemic Brain
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10747878
This study is looking at how certain brain cells called astrocytes help protect the brain and support healing after a stroke, with the hope of finding new ways to improve recovery for stroke patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10747878 on ClinicalTrials.gov |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in maintaining the blood-brain barrier and regulating blood flow in the brain after an ischemic stroke. The study focuses on understanding how changes in astrocytes contribute to brain damage and repair mechanisms following a stroke. By examining the molecular pathways involved, particularly the Wnt/beta-catenin signaling pathway, the research aims to uncover potential therapeutic targets that could enhance recovery and protect brain function. Patients may benefit from insights gained in this research that could lead to new treatments for stroke-related brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke or are at risk for stroke-related brain injuries.
Not a fit: Patients with non-ischemic strokes or other neurological conditions unrelated to ischemic brain damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery and protect brain function after a stroke.
How similar studies have performed: Previous studies have shown promising results in understanding the role of astrocytes in brain recovery, suggesting that this approach could lead to significant advancements in stroke treatment.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEGUM, GULNAZ — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: BEGUM, GULNAZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.