How asthma and viral infections affect children's lung health
Dysregulated asthmatic epithelial interferon responses to viruses drive exacerbation, T2 inflammation, and airway remodeling
This study is looking at how viral infections can make asthma worse in kids and wants to learn more about how their immune systems react, so we can find better ways to help them breathe easier when they get sick.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11006270 on NIH RePORTER |
What this research studies
This research investigates how viral infections trigger asthma exacerbations in children, particularly focusing on the immune responses of airway epithelial cells. It aims to understand the role of type 2 inflammation and interferon responses in asthma, especially in children with different asthma types. By examining how these immune responses differ in asthmatic children, the research seeks to identify better treatment strategies for managing asthma exacerbations and improving lung function.
Who could benefit from this research
Good fit: Ideal candidates for this research include children with asthma, particularly those experiencing frequent exacerbations triggered by viral infections.
Not a fit: Patients with asthma who do not experience viral-triggered exacerbations or those with non-asthmatic respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for asthma exacerbations, reducing emergency visits and hospitalizations for children.
How similar studies have performed: Previous research has shown promising results in understanding the immune responses in asthma, but this specific approach to studying interferon responses in relation to viral infections is relatively novel.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Debley, Jason S — Seattle Children's Hospital
- Study coordinator: Debley, Jason S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.