How arsenic exposure during pregnancy affects children's risk of allergic airway diseases
Official title: Impact of Maternal Arsenic Exposure on Offspring's Epigenetic Reprogramming of Allergic Airway Disease
Funded at University of Pittsburgh at Pittsburgh · NIH-11096012 · Data updated 2026-11-12
This study looks at how being exposed to inorganic arsenic during pregnancy might affect the development of asthma and other allergic airway issues in kids, aiming to understand how this exposure can change lung growth and immune responses in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 2, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $462,305 |
| NIH project number | 5R01ES034760-03 |
| Project ID | NIH-11096012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals who have been exposed to inorganic arsenic and their children.
✕Less likely to help
Patients who have not been exposed to arsenic or do not have a history of allergic airway diseases may not benefit from this research.
What this research studies
This research investigates the impact of maternal exposure to inorganic arsenic on the development of allergic airway diseases, such as asthma, in offspring. It focuses on understanding how prenatal arsenic exposure may lead to epigenetic changes that affect lung development and immune responses in children. By using animal models, the study aims to uncover the mechanisms through which arsenic influences respiratory health across generations. The findings could provide insights into preventing allergic conditions in children exposed to environmental toxins.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing allergic airway diseases in children exposed to arsenic.
How similar studies have gone: Previous research has indicated a link between environmental toxins and respiratory health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Tang, Wan-Yee — University of Pittsburgh at Pittsburgh
- Study coordinator: Tang, Wan-Yee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.