How arsenic exposure affects the 3D structure of our DNA and its role in cancer development
Molecular Underpinnings in the Establishment of an Oncogenic 3D Genome inResponse to Environmental Arsenic Exposure
This study is looking at how being around arsenic in the environment can change the shape of DNA and affect how our genes work, which might help explain how it could lead to cancer, so we can better understand and prevent these health risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10793571 on NIH RePORTER |
What this research studies
This research investigates how exposure to environmental arsenic alters the three-dimensional structure of DNA, which can lead to changes in gene expression and potentially contribute to cancer development. By examining the epigenetic modifications caused by arsenic, the study aims to understand the mechanisms through which this pollutant influences health. The research employs advanced techniques to analyze chromatin structure and gene regulation, providing insights into the biological effects of arsenic exposure. Patients may benefit from a better understanding of how environmental factors contribute to cancer risk and the development of preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of arsenic exposure or those living in areas with high environmental arsenic levels.
Not a fit: Patients who have no history of arsenic exposure or those with cancers unrelated to environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for arsenic-related cancers.
How similar studies have performed: Previous research has shown that understanding the epigenetic effects of environmental pollutants can lead to significant advancements in cancer prevention and treatment.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Fondufe-Mittendorf, Yvonne Nsokika — Van Andel Research Institute
- Study coordinator: Fondufe-Mittendorf, Yvonne Nsokika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.