How arsenic exposure affects sperm quality across generations
RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality
This study is looking at how exposure to inorganic arsenic during childhood and teenage years can affect sperm quality and potentially impact future generations, helping us understand how environmental toxins might influence reproductive health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-11035201 on NIH RePORTER |
What this research studies
This research investigates the impact of inorganic arsenic exposure on sperm quality, particularly focusing on how such exposure during adolescence and early life can affect not only the individual but also their future offspring. The study aims to understand the molecular mechanisms behind these intergenerational effects, specifically looking at RNA modifications in sperm that may carry these traits. By examining changes in small-RNAs and their modifications, the research seeks to uncover how environmental toxins like arsenic can influence reproductive health across generations.
Who could benefit from this research
Good fit: Ideal candidates for this research are males who have been exposed to arsenic, particularly during their adolescence or early life.
Not a fit: Patients who have not been exposed to arsenic or those who are not male may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of reproductive health issues linked to environmental toxins.
How similar studies have performed: While there is existing research on dietary influences on sperm quality, studies specifically addressing environmental toxins like arsenic and their intergenerational effects are limited, making this approach relatively novel.
Where this research is happening
Little Rock, United States
- Univ of Arkansas for Med Scis — Little Rock, United States (Active)
Researchers
- Principal investigator: Ho, Shuk-Mei — Univ of Arkansas for Med Scis
- Study coordinator: Ho, Shuk-Mei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.