How arsenic exposure affects heart disease risk in Native American communities
Official title: Epigenetic and genetic regulation of arsenic methylation and arsenic-relatedcardiovascular disease risk
Funded at Stanford University · NIH-11063205 · Data updated 2026-11-12
This study is looking at how arsenic in drinking water might increase the risk of heart disease, especially for Native American communities, and it aims to find out how our genes affect how our bodies handle arsenic, which could help us discover ways to prevent and treat heart problems related to arsenic exposure.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $125,847 |
| NIH project number | 5K99ES035109-02 |
| Project ID | NIH-11063205 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include Native American adults who have been exposed to arsenic through drinking water.
✕Less likely to help
Patients who do not have exposure to arsenic or are not part of the Native American communities may not benefit from this research.
What this research studies
This research investigates how arsenic in drinking water may contribute to cardiovascular disease (CVD) risk, particularly in Native American populations. It focuses on understanding the biological processes that influence how arsenic is metabolized in the body, specifically looking at genetic and epigenetic factors that affect this process. By analyzing data and biological samples from established studies, the research aims to identify biomarkers that could help predict arsenic-related health risks. Patients may benefit from insights that could lead to better prevention and treatment strategies for CVD linked to arsenic exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular disease in populations exposed to arsenic.
How similar studies have gone: Previous research has shown that understanding genetic and epigenetic factors can significantly impact disease risk, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Bozack, Anne Kristina — Stanford University
- Study coordinator: Bozack, Anne Kristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.