How arsenic affects cancer development through histone proteins
Molecular mechanisms of iAs-mediated carcinogenesis through the lens of histone H2B variants
This study looks at how arsenic, a common pollutant, affects our genes and may lead to cancer, aiming to find new ways to help people stay healthy and prevent illness from arsenic exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-11041146 on NIH RePORTER |
What this research studies
This research investigates how arsenic, a common environmental pollutant, influences gene expression and contributes to cancer development. The study focuses on the role of histone H2B variants in regulating chromatin accessibility, which is crucial for proper gene function. By understanding the molecular mechanisms behind arsenic-induced carcinogenesis, the research aims to uncover new insights into how environmental factors can lead to cancer. Patients may benefit from findings that could inform prevention strategies or treatments related to arsenic exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to arsenic, particularly through contaminated drinking water.
Not a fit: Patients who have not been exposed to arsenic or do not have a history of arsenic-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for cancers linked to arsenic exposure.
How similar studies have performed: Other research has shown success in understanding the role of environmental toxins in cancer, but the specific focus on histone H2B variants in relation to arsenic is relatively novel.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Fondufe-Mittendorf, Yvonne Nsokika — Van Andel Research Institute
- Study coordinator: Fondufe-Mittendorf, Yvonne Nsokika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.