How arginine affects the growth and function of pancreatic alpha cells
Arginine regulation of alpha cell proliferation and function
This study is looking at how the amino acid arginine affects the cells in the pancreas that produce glucagon, which can impact blood sugar levels, especially for people with diabetes, to help find new ways to manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11036371 on NIH RePORTER |
What this research studies
This research investigates the role of arginine, an amino acid, in the proliferation and function of alpha cells in the pancreas, which are responsible for producing glucagon. The study aims to understand how high levels of arginine influence these cells, particularly in the context of diabetes where glucagon secretion can lead to high blood sugar levels. By using specialized mouse models, researchers will explore the mechanisms behind arginine's effects on alpha cell behavior and how this might relate to diabetes management. Patients may benefit from insights that could lead to new treatments targeting glucagon regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who experience issues related to glucagon secretion and blood sugar regulation.
Not a fit: Patients who do not have diabetes or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing diabetes by targeting alpha cell function.
How similar studies have performed: Previous research has shown promising results in understanding the role of amino acids in pancreatic function, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Dean, Erika Danielle — Vanderbilt University Medical Center
- Study coordinator: Dean, Erika Danielle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.