How APOE4 affects Alzheimer's disease differently in men and women
Impact of APOE4 on gender-specific mechanism for Alzheimer's disease
This study is looking at how the APOE4 gene affects Alzheimer's disease differently in men and women, especially after menopause, to help find better treatments for those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11053937 on NIH RePORTER |
What this research studies
This research investigates the role of the APOE4 gene in Alzheimer's disease (AD), focusing on how it affects men and women differently. It aims to understand the mechanisms behind the increased prevalence of AD in women, particularly after menopause, and how hormones like follicle-stimulating hormone (FSH) may contribute to this risk. By studying the interactions between APOE4 and FSH, the research seeks to uncover potential pathways for developing targeted therapies for Alzheimer's. Patients may be involved in studies that explore these gender-specific biological factors and their implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for participation include postmenopausal women and men who are at risk for Alzheimer's disease due to genetic factors.
Not a fit: Patients who do not carry the APOE4 gene or are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, gender-specific treatments for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding gender differences in Alzheimer's disease, but this specific approach focusing on APOE4 and FSH is relatively novel.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Kang, Seong Su — Emory University
- Study coordinator: Kang, Seong Su
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.