How APOBEC3 enzymes cause mutations in breast, bladder, and other cancers
Molecular origins and impact of APOBEC3 mutagenesis in cancer
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11159688
Researchers want to understand how APOBEC3 proteins create mutation patterns in cancers like breast and bladder so future prevention and treatments can be improved.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11159688 on ClinicalTrials.gov |
What this research studies
This project looks at mutation patterns found across human cancer genomes and focuses on two common APOBEC3-related signatures seen in many tumors. The team uses tumor DNA data and human cancer cell lines that naturally show APOBEC3 activity to trace which APOBEC3 enzymes cause which mutations. They combine genomic analyses with laboratory assays to measure the contribution of individual APOBEC3 members to tumor mutations. Their goal is to connect enzyme activity with how cancers start, evolve, and respond to treatments.
Who could benefit from this research
Good fit: People with breast, bladder, or lung cancer, or patients willing to donate tumor samples or genomic data, would be most relevant to this work.
Not a fit: Patients with cancers that are not driven by APOBEC3-related mutations or those seeking immediate therapeutic benefit are unlikely to gain direct, short-term benefit from this project.
Why it matters
Potential benefit: If successful, the work could identify mutation processes that might be prevented, detected earlier, or targeted to improve cancer outcomes.
How similar studies have performed: Genomic studies have already identified APOBEC mutation signatures and links to clinical outcomes, but pinpointing the exact roles of specific APOBEC3 enzymes remains an active and emerging area.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACIEJOWSKI, JOHN — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: MACIEJOWSKI, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bladder Cancer, Breast Cancer, Breast Cancer cell line, Cancer Cause