How aortic stiffness affects heart and blood vessel health
Official title: Effects of aortic compliance and Windkessel reduction on cardiac and aortic pathophysiology
Funded at University of Nebraska Omaha · NIH-10691294 · Data updated 2026-11-12
This study is looking at how stiff aortic stent-grafts can affect your heart and blood vessels, and it aims to create a new type of stent-graft that feels more like your natural aorta to help keep your heart healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Omaha NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $581,104 |
| NIH project number | 5R01HL147128-05 |
| Project ID | NIH-10691294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have undergone or are candidates for aortic stent-grafting procedures.
✕Less likely to help
Patients who do not have aortic conditions or who are not undergoing stent-grafting procedures may not benefit from this research.
What this research studies
This research investigates the impact of aortic compliance and the Windkessel effect on heart and aortic health. It focuses on how stiff aortic stent-grafts can lead to increased heart workload and potential long-term damage. By developing a new type of stent-graft that mimics the natural elasticity of the aorta, the research aims to reduce harmful effects on the heart and improve overall cardiovascular function. Patients may be monitored for changes in heart structure and function as part of this investigation.
Why it matters
Potential benefit: If successful, this research could lead to improved stent-graft designs that better protect heart health and reduce complications for patients undergoing aortic interventions.
How similar studies have gone: Previous research has indicated that stent-grafts can have significant long-term effects on heart health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Nebraska Omaha
Omaha, United States Active
Researchers
- Principal investigator: Desyatova, Anastasia S — University of Nebraska Omaha
- Study coordinator: Desyatova, Anastasia S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.