How antifungal treatments and immune issues affect gut fungi
Effects of antifungal drug treatment and immune dysfunction on the evolutionary dynamics of gut-colonizing Candida glabrata
['FUNDING_R21'] · HACKENSACK UNIVERSITY MEDICAL CENTER · NIH-11119267
This study looks at how antifungal medications and a weakened immune system affect a fungus called Candida glabrata, which can cause infections in people who are sick, to help find better ways to treat those at risk of serious fungal infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HACKENSACK UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (HACKENSACK, UNITED STATES) |
| Trial ID | NIH-11119267 on ClinicalTrials.gov |
What this research studies
This research investigates how antifungal drug treatments and immune dysfunction influence the behavior of Candida glabrata, a fungus that can cause serious infections in people with weakened immune systems. By using a mouse model, the study aims to understand how these factors contribute to the evolution of drug resistance in this fungus. The findings could help identify better treatment strategies for patients at risk of invasive fungal infections, particularly those with compromised immune systems.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with immune dysfunction who are at risk of developing infections caused by Candida glabrata.
Not a fit: Patients with healthy immune systems and no history of fungal infections are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from invasive fungal infections.
How similar studies have performed: Previous research has shown that understanding the dynamics of fungal populations can lead to breakthroughs in treatment strategies, indicating that this approach has potential for success.
Where this research is happening
HACKENSACK, UNITED STATES
- HACKENSACK UNIVERSITY MEDICAL CENTER — HACKENSACK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHOR, ERIKA — HACKENSACK UNIVERSITY MEDICAL CENTER
- Study coordinator: SHOR, ERIKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.