How antifungal treatments and immune issues affect gut fungi
Official title: Effects of antifungal drug treatment and immune dysfunction on the evolutionary dynamics of gut-colonizing Candida glabrata
Funded at Hackensack University Medical Center · NIH-11119267 · Data updated 2026-11-12
This study looks at how antifungal medications and a weakened immune system affect a fungus called Candida glabrata, which can cause infections in people who are sick, to help find better ways to treat those at risk of serious fungal infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $265,650 |
| NIH project number | 1R21AI190958-01 |
| Project ID | NIH-11119267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with immune dysfunction who are at risk of developing infections caused by Candida glabrata.
✕Less likely to help
Patients with healthy immune systems and no history of fungal infections are unlikely to benefit from this research.
What this research studies
This research investigates how antifungal drug treatments and immune dysfunction influence the behavior of Candida glabrata, a fungus that can cause serious infections in people with weakened immune systems. By using a mouse model, the study aims to understand how these factors contribute to the evolution of drug resistance in this fungus. The findings could help identify better treatment strategies for patients at risk of invasive fungal infections, particularly those with compromised immune systems.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from invasive fungal infections.
How similar studies have gone: Previous research has shown that understanding the dynamics of fungal populations can lead to breakthroughs in treatment strategies, indicating that this approach has potential for success.
Where this research is happening
-
Hackensack University Medical Center
Hackensack, United States Active
Researchers
- Principal investigator: Shor, Erika — Hackensack University Medical Center
- Study coordinator: Shor, Erika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.