How anticholinergic medications affect saliva production and the role of genetics in dry mouth.
Impact of Anticholinergic Medication on Salivary Function; Exploring Potential Genetic Markers for Dry Mouth
This study is looking at how certain medications that older adults often take might affect saliva production and cause dry mouth, while also exploring if genetics play a role in how severe the dry mouth can be, so if you're taking these medications, your participation could help us learn more about your oral health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10873847 on NIH RePORTER |
What this research studies
This research investigates the impact of anticholinergic medications, which are commonly prescribed to older adults, on salivary function and the occurrence of dry mouth. It aims to identify genetic markers that may predict the severity of dry mouth in patients taking these medications. By analyzing data from a cohort of patients, the study seeks to understand the relationship between medication use, genetic factors, and oral health outcomes. Patients may be asked to provide saliva samples and undergo assessments to evaluate their salivary function and oral health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older, particularly those who are taking multiple medications with anticholinergic properties.
Not a fit: Patients who are not taking anticholinergic medications or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification and management of patients at risk for dry mouth, improving their quality of life and oral health.
How similar studies have performed: Previous research has indicated that anticholinergic medications can significantly impact salivary function, suggesting that this study's approach is grounded in established findings.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Arany, Szilvia — University of Rochester
- Study coordinator: Arany, Szilvia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.