How antibodies can protect against infections inside cells
Sialylated antibody defense against intracellular infections
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11058397
This study is looking at how special antibodies from mothers can help protect newborns and fetuses from infections, and it aims to find new ways to boost their immune systems for better treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11058397 on ClinicalTrials.gov |
What this research studies
This research investigates how sialylated antibodies can provide defense against intracellular infections, particularly in newborns and fetuses. It explores the role of maternal antibodies and their modifications during pregnancy that enhance immune responses. By understanding how these antibodies interact with neonatal B cells, the study aims to uncover new mechanisms of immunity that could lead to improved treatments for infections that are difficult to combat. The research employs advanced immunological techniques to analyze antibody behavior and its effects on immune cell activation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include newborns and fetuses at risk for intracellular infections.
Not a fit: Patients with fully developed immune systems or those not at risk for intracellular infections may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antibody-based therapies that enhance immune protection against intracellular infections in vulnerable populations like newborns.
How similar studies have performed: Previous research has shown promise in understanding antibody-mediated immunity, but this specific approach focusing on sialylated antibodies is relatively novel.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ERICKSON, JOHN J. — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: ERICKSON, JOHN J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.