How antibiotics affect the spread of drug-resistant bacteria in the gut
Antimicrobial Resistance and Horizontal Gene Transfer in the Human Gut Microbiome in Response to an Antibiotic
This study is looking at how taking antibiotics affects the bacteria in our gut and how that might lead to antibiotic resistance, helping us find better ways to use antibiotics and keep infections from becoming harder to treat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Palo Alto Veterans Instit for Research NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project ID | NIH-10841028 on NIH RePORTER |
What this research studies
This research investigates how the use of antibiotics influences the development and spread of antimicrobial resistance (AMR) in the human gut microbiome. By studying both in vivo responses to antibiotic exposure and in vitro analyses of stool-derived communities, the research aims to understand the mechanisms of horizontal gene transfer that contribute to AMR. The study employs innovative techniques to monitor genetic changes in bacteria before, during, and after antibiotic treatment, providing insights into the evolutionary dynamics of AMR. The ultimate goal is to enhance antibiotic stewardship and reduce the prevalence of drug-resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults over 21 who have been prescribed antibiotics and are willing to provide stool samples for analysis.
Not a fit: Patients who are not currently taking antibiotics or those with underlying conditions that affect gut microbiota may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing antibiotic use and reducing the incidence of drug-resistant infections.
How similar studies have performed: Previous research has shown promising results in understanding AMR dynamics in microbial communities, indicating that this approach could yield valuable insights.
Where this research is happening
Palo Alto, United States
- Palo Alto Veterans Instit for Research — Palo Alto, United States (Active)
Researchers
- Principal investigator: Relman, David a. — Palo Alto Veterans Instit for Research
- Study coordinator: Relman, David a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.