How antibiotics affect beneficial gut bacteria and immune function
Official title: Impact of antibiotic treatment on Lactobacillus population dynamics and intestinal T cell regulatory function
Funded at Emory University · NIH-10902645 · Data updated 2026-11-12
This study is looking at how the antibiotic ciprofloxacin affects good gut bacteria called Lactobacillus and how this might influence your immune system, so if you're taking this antibiotic, your participation could help us understand its effects on gut health better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI183823-01 |
| Project ID | NIH-10902645 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are prescribed ciprofloxacin for gastrointestinal infections and are interested in understanding the effects of antibiotics on their gut microbiota.
✕Less likely to help
Patients who are not receiving antibiotic treatment or those with conditions unrelated to gut health may not benefit from this research.
What this research studies
This research investigates the impact of the antibiotic ciprofloxacin on the population dynamics of Lactobacillus, a beneficial gut bacterium, and its role in regulating immune function. By analyzing samples from the intestines and feces of patients, the study aims to identify changes in bacterial diversity and the abundance of Lactobacilli during antibiotic treatment. The researchers will utilize advanced sequencing techniques to assess these changes and determine the resistance of different Lactobacilli species to ciprofloxacin. This work seeks to fill a critical knowledge gap regarding how antibiotics influence gut health and immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of how antibiotics affect gut health, potentially guiding better treatment strategies for patients receiving antibiotic therapy.
How similar studies have gone: Previous research has shown that antibiotics can significantly alter gut microbiota, but this specific investigation into Lactobacillus dynamics during ciprofloxacin treatment is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Rivera-Rodriguez, Dormarie — Emory University
- Study coordinator: Rivera-Rodriguez, Dormarie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.