How Anthrax Bacteria Invade the Body
Surface Proteins of Bacillus anthracis
This work explores how anthrax bacteria enter the body through the digestive system to help us find new ways to stop the infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11126748 on NIH RePORTER |
What this research studies
Our bodies have natural defenses, but anthrax spores can sometimes get past them, especially through contaminated food. This project looks closely at how these spores, and the bacteria they become, attach to and enter the cells lining our intestines. We are focusing on specific proteins on the surface of the bacteria that act like 'sticky hands,' helping them to bind and break through the protective layers in the gut. Understanding these steps is key to developing better ways to prevent or treat anthrax infections.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit anyone at risk of anthrax infection in the future.
Not a fit: Patients currently suffering from anthrax would not directly benefit from this basic science research, which focuses on understanding disease mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing anthrax infection or developing more effective treatments by targeting the bacteria's entry points.
How similar studies have performed: Other studies have identified various bacterial surface proteins involved in infection, suggesting that targeting these mechanisms can be a successful approach.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Missiakas, Dominique — University of Chicago
- Study coordinator: Missiakas, Dominique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.