How anion channels affect superoxide signaling in high blood pressure
Anion channel regulation of vascular superoxide signaling in hypertension
This study is looking at how certain channels in our cells help manage signals related to high blood pressure, which can lead to heart disease and stroke, with the goal of finding new ways to treat people dealing with hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11099885 on NIH RePORTER |
What this research studies
This research investigates the role of anion channels in regulating superoxide signaling related to hypertension, a condition that significantly increases the risk of heart disease and stroke. The study focuses on understanding how reactive oxygen species (ROS) interact with signaling molecules like Angiotensin II and tumor necrosis factor α, which are involved in the pathology of hypertension. By exploring the relationship between these channels and oxidative stress, the research aims to uncover new therapeutic targets that could improve treatment outcomes for patients with high blood pressure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hypertension or those at high risk for cardiovascular diseases.
Not a fit: Patients with normal blood pressure or those not experiencing cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage hypertension and reduce the risk of heart disease and stroke.
How similar studies have performed: Previous research has shown promising results in understanding the role of oxidative stress in hypertension, suggesting that this approach could yield significant insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Lamb, Fred S — Vanderbilt University Medical Center
- Study coordinator: Lamb, Fred S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.