How ANGPTL3 and ANGPTL8 control blood fats and cholesterol
Post-translational Control of Triglyceride and Cholesterol Metabolism by ANGPTL3 & ANGPTL8 in ApoBCL Clearance
Looks at whether targeting two proteins, ANGPTL3 and ANGPTL8, can lower blood triglycerides and cholesterol in people at risk for heart disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11249206 on NIH RePORTER |
What this research studies
If you have high triglycerides or cholesterol, this research aims to understand how two proteins (ANGPTL3 and ANGPTL8) affect the way your body clears blood fats. Researchers will study the forms and interactions of these proteins and how they change lipoprotein clearance using laboratory models and human genetic information. The team will link what they learn about protein function to the pathways that remove cholesterol and ApoB-containing particles from the blood. Ultimately the work seeks molecular clues that could guide new treatments to reduce heart disease risk.
Who could benefit from this research
Good fit: People with elevated triglycerides or cholesterol, including those with genetic lipid disorders or variants in ANGPTL3, would be the most relevant candidates.
Not a fit: People whose lipid problems are driven by unrelated causes or who already have well-controlled cholesterol on current treatments may not gain direct benefit from this work.
Why it matters
Potential benefit: Could point to new ways to lower triglycerides and cholesterol, which might reduce the risk of heart attack and stroke.
How similar studies have performed: Related approaches targeting ANGPTL3 have already shown promise in lowering triglycerides and LDL cholesterol in people, so this work builds on promising prior results.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Hobbs, Helen Haskell — Ut Southwestern Medical Center
- Study coordinator: Hobbs, Helen Haskell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.