How anesthetics affect the body's responses through specific receptors
Anesthetics' Effects on Physiological Responses Modulated by Peripheral GABAA Receptors
This study is looking at how anesthesia affects the body by interacting with certain receptors, which could help us understand and reduce side effects like low blood pressure during surgery, making it safer for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11031934 on NIH RePORTER |
What this research studies
This research investigates how anesthetics, commonly used during surgeries, influence physiological responses by interacting with GABAA receptors located in peripheral organs. The study aims to understand the mechanisms behind the side effects of anesthetics, such as hypotension, which can be dangerous for patients. By exploring the direct effects of anesthetics on these receptors in immune cells and smooth muscle, the research seeks to improve patient safety during anesthesia. The approach includes both laboratory experiments and analysis of physiological responses to better understand these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing surgical procedures that require anesthesia.
Not a fit: Patients who are not undergoing surgery or do not require anesthesia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer anesthesia practices, reducing the risk of life-threatening side effects during surgical procedures.
How similar studies have performed: While the effects of anesthetics on the central nervous system are well-studied, the specific interactions with peripheral GABAA receptors are less understood, making this research a novel exploration in the field.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Emala, Charles W — Columbia University Health Sciences
- Study coordinator: Emala, Charles W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.