How AMPK affects energy balance and metabolism in cells
The functional role of mTORC1 regulation by AMPK in cellular metabolic reprogramming
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10928173
This study is looking at how a protein called AMPK helps keep our cells' energy balanced, which is important for preventing diseases like diabetes and cancer, and it hopes to find new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10928173 on ClinicalTrials.gov |
What this research studies
This research investigates the role of AMP-activated kinase (AMPK) in regulating cellular energy balance, which is crucial for preventing diseases like diabetes and cancer. It focuses on how AMPK influences the mechanistic Target of Rapamycin complex 1 (mTORC1) pathway, which is involved in cell growth and metabolism. By understanding these mechanisms, the research aims to clarify how energy homeostasis is maintained in cells under stress conditions. Patients may benefit from insights that could lead to new treatments for metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders, including diabetes and certain types of cancer.
Not a fit: Patients with stable metabolic conditions or those not affected by energy homeostasis issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing diseases related to energy imbalance, such as diabetes and cancer.
How similar studies have performed: Previous research has shown promising results in understanding AMPK's role in metabolism, indicating that this approach has potential for significant advancements.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN NOSTRAND, JEANINE L — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: VAN NOSTRAND, JEANINE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers