How Alzheimer's disease affects different types of brain cells in memory processing
Differential impact of Alzheimer disease on neuronal subpopulations in dorsal hippocampal CA1
This study is looking at how Alzheimer's disease affects certain brain cells in mice, especially those involved in memory, to help us understand why memory problems happen and find new ways to help people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11083761 on NIH RePORTER |
What this research studies
This research investigates the impact of Alzheimer's disease on specific types of neurons in the dorsal hippocampus, particularly focusing on the differences between superficial and deep pyramidal neurons. By using mouse models of Alzheimer's, the study aims to understand how these neurons respond to the disease and how their dysfunction contributes to memory loss. The researchers will analyze the changes in these neurons due to amyloid and tau pathology, which are key features of Alzheimer's. This work seeks to uncover the mechanisms behind memory deficits in Alzheimer's patients and identify potential targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating memory loss in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding neuronal diversity in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Masurkar, Arjun Vijay — New York University School of Medicine
- Study coordinator: Masurkar, Arjun Vijay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.